Alvarez-Builla, Julio


Julio Alvarez-Builla

Emeritus Professor. Department of Organic Chemistry. University of Alcala. Alcala de Henares Madrid. Spain

Julio Alvarez-Builla obtained his Ph.D. in the area of Organic Chemistry in 1976, at the University Complutense of Madrid, working in analogs of natural alkaloids. Then, he spent a Postdoctoral stage with Prof. A. R. Katritzky, at the University of East Anglia, over the years 1978-1979, working in the synthesis of heterocyclic derivatives.

Back in Madrid, in 1981 he organised the group of Heterobetaines, a group devoted to the design and synthesis of organic compounds, doing basic research linked to industrial developments.

From 1992 onwards, J. Alvarez-Builla directed the project of the Pilot Plant of Fine Chemicals –today Centre of Applied Chemistry and Biotechnology, CQAB-, at the University of Alcalá, an institute devoted to custom research, in collaboration with mainly pharmaceutical companies. The facility was inaugurated in 1998, and he was the Scientific Director up to 2009, and continues consulting and leading projects in the centre.

In 1993, he got a professorship in Organic Chemistry at the same University. During the period 1995-1998 he became Vicerrector of Research, and from 1998-2000 was Vicerrector of Scientific&Technological Development, devoted to implement the University-enterprise collaboration, all in the same University. From 2009 to 2012, he has been Dean of the Faculty of Pharmacy.

Prof. Alvarez-Builla has actively stimulated industrial relationships, and he has collaborated/directed up to now in more than 130 projects and contracts, many of them with leading international pharma companies such as Ely&Lilly, GlaxoSmithKline, Janssen-Cilag, Sanofi-Synthelabo, Almirall-Prodesfarma, Servier and others. Moreover, he has been consultant of several companies, mainly Lilly S. A. (Madrid)(1999-2006), and St. Charles Pharmaceuticals (N. Orleans, USA)(2000-), being at present member of the scientific committee of the Lilly Foundation. (2002-).

He has been coeditor, with profs. J. J. Vaquero, and J. Barluenga and author of several chapters of the book “Modern Heterocyclic Chemistry” in 4 volumes. (Wiley-VCH Verlag GmbH (2011) ISBN 978-3-527-33201-4). He also has published more than 200 papers in leading journals of organic and medicinal chemistry as: Journal of Organic Chemistry, Organic Letters, Tetrahedron Letters, Tetrahedron, Chemical Communications, European Journal of Organic Chemistry, Synlett and Synthesis, as well as in Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry or QSAR. As a result of his collaborations with industry, he has produced up to now 43 patents –extended to 116 in numerous countries-, in diverse areas of Organic and Medicinal Chemistry. At present is member of the Editorial board of ARKIVOC (USA).

His interests have been directed to the synthesis of heterocycles and derivatives of therapeutic interest, as well as to the introduction of new technologies in organic synthesis: Phase Transfer Catalysis, Ultrasound, Microwaves. In relation with his work in the CQAB, he is developing green processes of drug synthesis, to be industrially applied in the near future.