Castells, Mariana


Mariana Castells

Clinician, researcher and teacher at Brigham and Women’s Hospital and Dana Farber Cancer Institute. She is the director of the Drug Hypersensitivity and Drug Desensitization Center, as well as the director of the Mastocytosis Center, and has served as the Allergy and Immunology Training Program Director for 20 years.  She served on the Board of Directors of the AAAAI and is at the council of the International College of Allergy (CIA) and has directs the International Drug Desensitization Meeting (DDIM) in Barcelona, Spain for the last 7 years.

She has spearheaded the evaluation and understanding of drug anaphylaxis and hypersensitivity and provided desensitization protocols which are used as standards around the world, treating thousands of patients with cancer and chronic inflammatory diseases, maintaining these patients on their first line therapy. Her research has uncovered mast cell inhibitory mechanisms which are pertinent to desensitization. She has been involved in the new diagnostic criteria for mast cell activation disorders and mastocytosis and heads clinical trials created the Mastocytosis Center.