Esteban, Mariano


Mariano Esteban

Actual Professor and Head of Poxvirus and Vaccines Program. Centro Nacional de Biotecnología (CNB) – CSIC. Madrid

06/1970, PhD at University of Santiago, Spain/ National Institute for Medical Research, UK, Rutgers Medical School, University of Gent, Belgium


1993-2003, Director, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain. 1985-1994, Professor, Departments of Biochemistry and of Microbiology and Immunology, Downstate Medical Center, SUNY, New York. 1982-1985, Associate Professor, Departments of Biochemistry and of Microbiology and Immunology, Downstate Medical Center, SUNY, New York. 1979-1982, Assistant Professor, Departments of Biochemistry and of Microbiology and Immunology, Downstate Medical Center, SUNY, New York. 1978, Visiting Professor, Laboratory of Molecular Biology, Gent, Belgium. 1974-1977, Instructor, Department of Microbiology, Rutgers Medical School, New Jersey. 1970-1974, Research Associate, Virology and Biochemistry Divisions, National Institute for Medical Research, MRC, Mill Hill, London, UK.

Scientific interests

Prof. Esteban is a well-recognized scientist with a long experience in molecular basis of pathogenesis by infectious agents and in translational research. In particular, his group has made major contributions in the biology of vaccinia virus, the mechanism of action of interferons and development of vaccines against major diseases like HIV/Aids, hepatitis C, chikungunya, malaria and leishmaniasis, some of which have advanced to phase I clinical trials (HIV).

Prof. Esteban has published over 340 articles in prestigious journals presented over 300 communications to international meetings and has given many seminars worldwide. He is a Member of a number of prestigious scientific international societies, Member of Editorial Boards and peer-review in major journals. He is also a Member of European and Spanish organizations.  He has organized international scientific meetings: President of XI International Poxvirus and Iridovirus Meeting, Toledo, 1996; President of the Fifth European Conference on Experimental AIDS Research (ECEAR-2000), Madrid; Vice-president of the European Virology meeting in Madrid, in 2004; Co-Chair of the 7Th Vaccine and ISV Congress-2013, Sitges, Spain. He participates in academic activities at the Autonomous University of Madrid, is member of the Royal Academy of Pharmacy of Spain (RANF) and in 2012 was elected President of RANF, and is also founder of EuroVacc.

The group of Prof. Esteban at the CNB-CSIC has developed candidate vaccines against HIV/AIDS based on poxvirus vectors (MVA and NYVAC) that have shown excellent immunological profiles in animal models (mouse and macaques) and efficacy against simian immunodeficiency virus in macaques.  Moreover, some of these vectors have entered phase I clinical trials, both prophylactic and therapeutic, giving good HIV-specific immune responses in most of the volunteers. Further improvement of the immunization protocols has been achieved in monkeys. The aim is to enter phase II clinical trials with some of the Esteban´s developed candidate vaccines in the next few years.

“Our current research is directed to translate basic science into clinical applications, optimizing the immunogenicity of the poxvirus vectors MVA and NYVAC, identifying immune mechanisms and correlates of protection. The goal is to develop and select the best-in-class immunogens leading to vaccine candidates against prevalent human diseases.

We maintain a fruitful collaboration with HIV vaccine experts in the USA and Europe through CAVD projects financed by Bill and Melinda Gates Foundation and the EU H2020 programs, as well as with other EU colleagues developing ebola and chikungunya vaccines.”