He earned his M.D. degree from the University of Seville, Spain, in 1977. He received postdoctoral training in Immunology at the University of Texas Southwestern Medical Center, Dallas (1979–1984) and residency training in Anatomical Pathology at Washington University in St Louis (1985–1990). In 1987, he joined the laboratory of Stanley Korsmeyer at Washington University in Saint Louis, where he studied the function of the anti-apoptotic protein BCL-2. In 1991, he joined the Department of Pathology at the University of Michigan in Ann Arbor as an Assistant Professor and was promoted to full Professor in 2001. He holds the Paul de Kruif Endowed Professorship in Academic Pathology. His laboratory identified NOD1 and NOD2, the first members of the Nod-like receptor (NLR) family, a class of pattern-recognition receptors that mediate cytosolic sensing of microbial organisms. Nuñez and colleagues showed that genetic variation in a NLR family member, NOD2, is strongly associated with susceptibility to Crohn’s disease. Currently, the Nuñez laboratory is interested in signaling pathways regulating innate immunity, host-microbial interactions, the pathogenesis of inflammatory disease and the role of the microbiota in host defense and disease. Dr. Nuñez is the author of more than 350 scientific publications (96,000 citations; h-index: 145; Google Scholar). A prolific speaker, Dr. Nuñez has given more than 450 scientific lectures in which he was the keynote speaker in 14. He has mentored more than 100 scientists including 54 postdoctoral fellows. The great majority of his trainees are independent investigators and members of the Faculty of academic institutions in the United States, Europe and Asia. His research program is supported by grants from the National Institutes of Health.