14 febrero, 2019 Mayte Martínez

Guadalupe Sabio

BsC in Veterinary Medicine at the Univ Extremadura, where I did Master’s thesis, which was awarded the prize for the best Master’s Thesis of the University (2001) (FEBS Lett and PNAS, in which I was first and second author). Dr. Sabio obtained her PhD in the British Medical Research Council in Dundee and Univ Extremadura under the supervision of Ana Cuenda, in Philip Cohen´s department where I learned how to study protein phosphorylation and to find new kinase substrates. There, I discovered several substrates of p38g and p38d and became an expert in protein interactions and in finding novel in vitro and in vivo substrates. I described for the first time that SAP97 was p38g substrate and the phosphorylation regulates its scaffolding functions. This work is documented by first-author publications in Biochem J (2004) and EMBO J (2005), J cell science (2010) and as a co-author in JBC (2005) and FEBS J (2009).  I also received the award for the best PhD Thesis at the Univ of Extremadura (2005).

After obtaining her PhD, I moved to the UMASS (Worcester, MA, USA), to study the in vivo function of MAPK with Dr. Roger Davis. I made important contributions to the understanding of the role of JNK1 in different tissues and its implication in diabetes. This progress was reflected in several first-author publications. In Science (2008), I described the effects of JNK1 deficiency in adipose tissue, and also obtained a related patent. This work has been reviewed in two leading journals (Science and Hepatology). In Cell Metab (2009), I described the effects of JNK1 deficiency in the liver (also reviewed in Hepatology).  I also demonstrated that JNK1 deficiency in muscle results in increased insulin sensitivity (Mol Cell Biol 2010). In addition, I demonstrated that lack of JNK1 in brain leads to increase circulating levels of T3 (Genes and development, 2010). I also wrote a review summarizing the role of JNK in metabolism (Trends Biochem Sci 2010). I also worked on the role of p38MAP kinases, in collaboration with Dr Mercedes Rincón, at Vermont. (Science 2008, Int J Biol Sci 2009, J Immunol 2011 Blood 2011) and collaborated on other projects (second authorship in Cell (2009) and the role of JNK1 and JNK2 in liver Cell metabolism 2014.

Afterwards, I established as an independent PI at CNIC, thanks to the award of an ERC Starting Grant. She also got other important National and international Grants:  a 3 MICINN-SAF Projects, two European Association for the Study of Diabetes projects. Also, I obtained a collaboration grant from the CAM.  Right now, I work in the role of stress kinases in the development of metabolic diseases and cancer trying to understand the network of this pathway. I have published several papers as corresponding senior author in  the  Journal  Clinical  Investigation  (2013)  in  which  we  show  that  these  kinases  control  TNF  production through the phosphorylation of eEF2K, in Nature Communications (2016) in which we demonstrate that p38g/d control heart growth by the phosphorylation and degradation of the mTOR inhibitor, DEPTOR, in EMBO J (2016) in which we demonstrate that p38g/d are activated in liver during steatosis, Nature Communications (2017) where I found the role of MKK6 in white adipose tissue browning and Plos Biol 2018 in which we described the role of p38d in Brown adipose tissue activation. And recently a manuscript describing the role of p38g in liver cancer has been accepted in Nature.  I wrote several revisions Seminars in Immunology (2014) J Mol Endocrinol.  My research has received already very important awards as Loreal- Unesco Spain. 2010; and Principe de Girona 2012 award of Science, and the star of Madrid. She has also been awarded by the Spanish Society of Biochemistry and Molecular Biology (SEBBM) 2016. Recently she was honor as a EMBO Young Investigator, and two award for her research Astra Zeneca young investigator 2018, Jesus Serra award 2018.