He did his postdoctoral training at Harvard Medical School, Boston, Massachusetts, USA. He is Professor of Immunology at the Universidad Autonoma de Madrid, Spain, Chief of Service of Immunology and the Scientific Director of the Hospital Princesa Research Institute, Madrid, Spain.
Francisco Sanchez-Madrid has made leading contributions to knowledge about the mechanisms of leukocyte adhesion, polarity, migration and activation. This contribution has pioneered the identification and characterization of the first families of leukocyte adhesion molecules, their physiological role in the control of migration and cellular traffic, and their immense relevance to chronic inflammatory pathologies.
Sanchez-Madrid laboratory research on migration and activation receptors of human leukocytes is documented in more than 420 publications in international journals, including many recent articles in prestigious journals that have to date received more than 27.500 citations.
In the most recent years, his research group has made key contributions to understanding the functional relevance of the supra-molecular organization of leukocyte and endothelial nanoplatforms connected to cytoskeleton in the regulation of cell-to-cell communication in the immune system and the mechanisms. More recently, Sanchez-Madrid has extended his area of research to novel forms of cell-to-cell communication in the immune system, including the transfer of genetic information through antigen-dependent contacts. A major breakthrough was the demonstration that genetic information is transferred between T cells and antigen-presenting cells contained in exosomes harbouring specific repertoires of proteins, mRNAs and miRNAs.
Sanchez-Madrid’s leadership capacity is demonstrated by the fact that more than twenty five of the select group of investigators trained in my lab are now university professors and research group leaders in their own right in national and international centres. Finally, Sánchez-Madrid has consistently shown his commitment to the management and promotion of scientific research in Spain and Europe. He has served as President of the Immunology Commission of the Spanish Health Research Fund (Fondo de Investigación Sanitaria; FIS, 1998-2000), Coordinator of the National Biomedicine Plan (Plan Nacional de Biomedicina, 2001-2005), and Member of the Evaluation Panel LS6 of European Research Council for Young Investigator Grants (2007-2010).