He is Professor of Biological Sciences and Neuroscience at Columbia University. He was born in Madrid, where he obtained his MD at the Universidad Autónoma. After a brief period in Sydney Brenner’s laboratory in Cambridge, UK, he performed Ph.D. studies with Larry Katz in Torsten Wiesel’s laboratory at Rockefeller University and was a postdoctoral student of David Tank at Bell Labs. In 1996 he joined the Department of Biological Sciences at Columbia University, where he is Full Proefessor. In 2005 he became HHMI Investigator and co-director of the Kavli Institute for Brain Circuits and in 2014 Director of the Neurotechnology Center at Columbia. Yuste is interested in the endogenous function of neural circuits, using both mouse visual cortex and Hydra vulgaris as experimental preparations. To study these questions, Yuste has pioneered the development of imaging techniques, such as calcium imaging of neuronal circuits, two-photon imaging of spines and circuits, photostimulation using inorganic caged compounds, two-photon optogenetics and holographic spatial light modulation microscopy. Yuste has obtained many awards for his work, including New York City Mayor’s, the Society for Neuroscience’s Young Investigator and the NIH Director Pioneer Awards. Finally, he led the group of researchers who proposed the Brain Activity Map Project, sponsored by the White House’s as its BRAIN initiative.